Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis
نویسندگان
چکیده
منابع مشابه
MicroRNA-370 directly targets FOXM1 to inhibit cell growth and metastasis in osteosarcoma cells.
MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs, which play a critical role in regulating varieties of the biological and pathologic processes. Several reports have indicated that miR-370 acts as a tumor suppressor in varieties of tumors. However, the roles of miR-370 in osteosarcoma have not been reported. In this study, our objective was to explore the biological functions and its m...
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Aim: To explore the expression and clinical significance of Zeb1 and Zeb2 in osteosarcoma (OS). Materials and methods: In our study, we detected the expression of Zeb1 and Zeb2 in 120 cases of OS tissues with immunohistochemistry, and divided the cohort into Zeb1 or Zeb2 high/low expression group according to the cut-off. Moreover, we evaluated the clinical significance of Zeb1/Zeb2 by analyzin...
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MiR-429 functions as a tumor suppressor and has been observed in multiple types of cancer, but the effects and mechanisms of miR-429 in osteosarcoma are poorly understood. This study is performed to evaluate the functions of miR-429 in the progression of osteosarcoma. Firstly, the miR-429 expression in osteosarcoma tissues and osteosarcoma cells was detected using real time PCR, and the relatio...
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ژورنال
عنوان ژورنال: Aging
سال: 2018
ISSN: 1945-4589
DOI: 10.18632/aging.101710